| 摘要 |
A system for administering a bioactive compound by inhalation comprising: (a) a composition comprising the biologically-active compound and a lipid mixture; and (b) an inhalation delivery device; wherein the lipid mixture comprises: (1) a first mixture comprising phosphatidylcholine, negativelycharged lipid, and sterol in the molar ratio of 1-20: 1-10: 0.5-5; (2) a second mixture comprising phosphatidylcholine, negatively-charged lipid and albumin in the molar ratio of 1-20: 1-10: 0.1-10; (3) a third mixture comprising phosphatidylcholine, positively-charged lipid and phosphatidylethanolamine in the molar ratio of 1-20: 0.520:1-10; (4) a fourth lipid mixture having phosphatidylcholines: negatively-charged lipids: phosphatidylethanolamines in the molar ratio of 1-20: 1-10: 110; (5) a fifth lipid mixture having phosphatidylcholines: positively-charged lipids: albumin compounds in the molar ratio of 1-20: 0.5-20: 0.1-10; or (6) a sixth lipid mixture having phosphatidylcholines: positively-charged lipids: sterol compounds in the molar ratio of 1-20: 0.5-20: 0.5-5. wherein the bioactive agent lipid mixture weight ratio is from 10: 1 to 1: 500.
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