| 摘要 |
Disclosed herein is orally administrable suspension of a non-steroidal anti-inflammatory drug (NSAID) selected from the group of propionic acid derivatives, acetic acid derivatives, fenamic acid derivatives, biphenylcarboxylic acid derivatives, acid enolcarboxamides, diaryl-heterocycles with methyl-sulphonyl or aminosulphonyl substituents and acid sulphanomides and their salts, in a physiologically inert dispersion medium in which the solubility of the NSAID is low, so that the suspension has no detectable inherent taste, contains (a) a small amount of finely divided silica, which is added the dispersion medium under high shear conditions to form a suspension-stabilizing 3-dimensional solid structure, and (b) a small amount of a soluble hydrophilic polymer. Also disclosed is the production of an orally administrable liquid NSAID formulation in the form of a stabilized suspension by (i) grinding the NSAID so that at least 90% of the particles are smaller than 50 mm, (ii) suspending the ground NSAID in a physiologically inert dispersion medium in which the solubility of the NSAID is low, (iii) adding a small amount (0.1 to 5%) of finely divided silica under high shear conditions, (iv) adding a small amount (0.05 to 2%) of a soluble hydrophilic polymer such as cellulose ether , and (v) adding one or more flavors, sweeteners, excipients and/or preservatives.
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