Benzoxazine and benzothiazine derivatives and their use for treating diseases triggered by NOS

摘要

Aminoalkylaminoalkyl-substituted 3-amino-1,4-benzoxazine or -benzothiazine derivatives (I), their tautomers, isomers and salts that are useful or treating diseases triggered by NOS and a method of preparation thereof are disclosed, wherein: X = O, SOm or Se; R1 = -(CHR9)n-NR7-A-NR8-B8; R2 = H; or R1 & R2 together with adjacent carbon atom form ortho-fused 5-8 membered ring, which is monocyclic or bicyclic, saturated or unsaturated in which 1 or 2 CH2 groups may be replaced by O or carbonyl, and which is substituted by -CHR9r-NR7-A-NR8-B and optionally substituted with C1-4 alkyl; R4 is H or acyl; m is 0, 1 or 2: n or r are 0 or 1-6; and wherein B, R3, R5, R6, R7, R8 and R9 are as defined in the specification.