发明名称 |
Methods for predicting functional and structural properties of polypeptides using sequence models |
摘要 |
The invention provides a method for identifying a polypeptide that binds a ligand. The method includes the steps of (a) comparing a sequence of a polypeptide to a sequence model for polypeptides that bind a ligand, wherein the sequence model comprises representations of amino acids consisting of a subset of amino acids, the subset of amino acids having one or more atom within a selected distance from a bound ligand in the polypeptides that bind the ligand; and (b) determining a relationship between the sequence and the sequence model, wherein a correspondence between the sequence and the sequence model identifies the polypeptide as a polypeptide that binds the ligand.
|
申请公布号 |
US2003162219(A1) |
申请公布日期 |
2003.08.28 |
申请号 |
US20010040895 |
申请日期 |
2001.12.28 |
申请人 |
SEM DANIEL S.;BAKER BRIAN;HANSEN MARK R. |
发明人 |
SEM DANIEL S.;BAKER BRIAN;HANSEN MARK R. |
分类号 |
G01N33/68;G06F19/00;(IPC1-7):G01N33/53;G01N33/48;G01N33/50 |
主分类号 |
G01N33/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|