摘要 |
This invention features a compound of the following formula T-(-L-C)m, where in T is a transportophore (a transport mediating molecule), L is a a non- antibiotic therapeutic agent, and m is l- 8, in which the transportophore ha s an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, a nd the compound has an immune selectivity ratio of at least 2. Figure 1 depicts comparison of selective uptake of diverse structure types into white blood cells from a complex blood mix.
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申请人 |
SYMPORE GMBH |
发明人 |
BUSCH, MAXIMILIAN;GUTKE, HANS-JURGEN;GUSE, JAN-HINRICH;BARKER, LAURENCE;BURNET, MICHAEL;BECK, ALBERT;KHOBZAOUI, MOUSSA;MARGUTTI, SIMONA;WOLFF, MICHAEL;MEINDL, THOMAS;KIM, GENE;LUYTEN, KATTIE;REICHERT, JEANNETTE;TSOTSOU, GEORGIA;DROSTE-BOREL, IRINA |