| 摘要 |
1. A preparation in powder form for administration through mucosa, comprising a medicine of high molecular weight and a copolymer of aminoalkylmethacrylate or polyvinyl acetal diethylaminoacetate. 2. The preparation of claim 1, wherein comprising from 0.1 to 90 wt % of the copolymer of aminoalkylmethacrylate or polyvinyl acetal diethylaminoacetate. 3. The preparation of claim 1, wherein comprising from 1 to 50 wt % of the copolymer of aminoalkylmethacrylate or polyvinyl acetal diethylaminoacetate. 4. The preparation of any one of claims 1 to 3, wherein promotes the absorption of a high molecular weight medicine through mucosa. 5. The preparation of claim 1, further comprising a viscous polymer. 6. The preparation of claim 5, wherein the viscous polymer is hydroxypropylmethyl cellulose. 7. The preparation of claim 1, wherein the medicine of high molecular weight is selected from the group consisting of bioactive peptides and proteins, antibodies, vaccines, and antigens. 8. The preparation of claim 7, wherein the medicine of high molecular weight is selected from the group consisting of calcitonin, insulin, proinsulin, vasopressin, desmopressin, luteinizing hormone, luteinizing hormone-releasing hormone, somatostatin, prolactin, glucagon, gastrin, secretin, kallikrein, urokinase, neurotensin, enkephalin, kyotorphin, endorphin, endothelin, angiotensin, transferrin, atrial natriuretic polypeptide, epithelial cell growth factor, growth hormone, parathyroid hormone, interferons, interleukins, tumor necrosis factor, leukemia inhibitory factor, hematopoietic stem cell growth factor, erythropoietin, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage-stimulating factor, macrophage colony-stimulating factor, thrombopoietin, superoxide dismutase, tissue plasminogen activator, antithrombin, blood coagulation factors, anti-IgE antibodies, anti-IgA antibodies, anti-tumor antibodies, antibodies to tumor necrosis factor, anti-interleukin antibodies, HIV-neutralizing antibodies, anti-platelet antibodies, anti-hepatitis virus antibodies, hepatitis vaccines, influenza vaccines (influenza antigens), pertussis vaccine, diphtheria vaccine, tetanus toxoids vaccine. 9. The preparation of claim 7, wherein the antigen is peptide or protein which may act as antigen, such peptide or protein conjugated to haptens, and mixtures of such peptides, proteins or conjugates with adjuvants. 10. The preparation of any one of claims 1-9, which is a preparation for pernasal administration.
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