RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

摘要

The present invention concerns methods and reagents useful in modulating BCL2 gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against BCL2, BCL-XL, MCL-1, BCL2-Ll, CED-9, BAG-1, ElB-194 and/or BCL-A1 gene expression, useful in the treatment of cancer and any other condition that responds to modulation of BCL2, BCL-XL, MCL-1, BCL2-Ll, CED-9, BAG-1, E1B-194 and/or BCL-A1 expression.