ENHANCING NEUROTROPHIN-INDUCED NEUROGENESIS BY ENDOGENOUS NEURAL PROGENITOR CELLS BY CONCURRENT OVEREXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR AND AN INHIBITOR OF A PRO-GLIOGENIC BONE MORPHOGENETIC PROTEIN

摘要

The present invention relates to a method of inducing neuronal production in a subject, a method of recruiting neurons to a subject's brain, and a method of treating a neurodegenerative condition by administering a neurotrophic factor and an inhibitor of pro-gliogenic bone morphogenetic proteins. Also disclosed is a method of suppressing astrocyte generation and inducing neuronal production in a subject, a method of treating a neurologic condition, and a method of suppressing glial scar formation in a subject by administering an inhibitor of pro-gliogenic bone morphogenetic proteins. Finally, the present invention involves a method of introducing a heterogenous protein into a subject's brain and spinal cord by introducing a nucleic acid molecule encoding the heterogenous protein introduced into the subject's ependyma, permitting the protein from the nucleic acid molecule to be expressed within the subject's ependyma, and permitting the expressed protein to migrate within the subject's brain and spinal cord.