RNA INTERFERENCE MEDIATED INHIBITION OF GRB2-ASSOCIATED BINDING PROTEIN 2 (GAB2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

摘要

The present invention concerns methods and reagents useful in modulating of GRB2 associated binding protein (GAB2) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro­RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against of GRB2 associated binding protein (GAB2) gene expression and/or activity. The siNA molecules are useful in the treatment of allergic conditions, inflammatory conditions, cancer and any other condition that responds to modulation of GAB2 expression or activity.