发明名称 |
METHOD OF RESOLVING OPTICAL ISOMERS OF AMINO ACID DERIVATIVE |
摘要 |
Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type and an L type are present in a mixture with a hydrophilic compound such as beta -cyclodextrin having a different affinity to two kinds of the optical isomers described above and then bringing the resulting aqueous solution or aqueous suspension into contact with a hydrophobic substance such as a solid matter subjected on a surface thereof to hydrophobic treatment on the condition that the pH is 3.5 or lower or under the coexistence of ions including an atomic group having hydrophobicity which can be a counter ion for the amino acid derivative described above such as a triethylammonium ion to thereby separate the D type amino acid derivative from the L type amino acid derivative present in the above aqueous solution or aqueous suspension.
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申请公布号 |
EP1338588(A1) |
申请公布日期 |
2003.08.27 |
申请号 |
EP20010980906 |
申请日期 |
2001.10.25 |
申请人 |
TOKUYAMA CORPORATION |
发明人 |
WATANABE, SHIN;KAWAHARA, MIZUE |
分类号 |
C07C231/20;C07D207/16;C07B57/00;C07C233/83;C07C269/08;C07C271/22;C07C319/28;C07C323/52;C07C323/58;C07C323/59;C07D209/20;(IPC1-7):C07C231/20;C07M7/00 |
主分类号 |
C07C231/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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