| 发明名称 |
Mutated herpes simplex virus type 1 thymidine kinases and uses thereof |
| 摘要 |
The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.
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| 申请公布号 |
US6610289(B2) |
申请公布日期 |
2003.08.26 |
| 申请号 |
US20010877381 |
申请日期 |
2001.06.08 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
DRAKE RICHARD;HINDS TRENTON;COMPADRE CESAR;HURLBURT BARRY;RECHTIN TAMMY |
| 分类号 |
A61K48/00;C12N9/12;(IPC1-7):A01N63/00;A01N43/04;C12N15/00 |
主分类号 |
A61K48/00 |
| 代理机构 |
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