NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS
摘要
The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.
申请公布号
WO0229001(A3)
申请公布日期
2003.08.21
申请号
WO2001US30936
申请日期
2001.10.03
申请人
UNIVERSITY OF VIRGINIAN PATENT FOUNDATION;LYNCH, KEVIN, R.;MACDONALD, TIMOTHY, L.;HEISE, CHRISTOPHER, E.;SANTOS, WEBSTER, L.;OKUSA, MARK, D.
