Combination preparations, useful for the treatment of protozoal infections, especially malaria, comprise a lincosamide antibiotic such as clindamycin and a dispiro-tetraoxane compound, e.g. TetA

摘要

Pharmaceutical combination preparations (A), useful for treating parasitic protozoal infections, comprise a lincosamide antibiotic (I) and a dispiro-1,2,4,5-tetraoxane compound (II), for simultaneous, separate or successive administration. Pharmaceutical combination preparations (A), useful for treating parasitic protozoal infections, comprise a lincosamide antibiotic (I) and a tetraoxane compound of formula (II), for simultaneous, separate or successive administration. R1-R24 = H, OH or halo; or 1-26C alkyl, 1-26C alkoxy, 1-26C alkoxyalkyl, 1-26C hydroxyalkyl, aryl, acyl, aralkyl, 2-26C alkenyl, 2-26C alkynyl, cycloalkyl, heterocyclyl or silyl; and i, j, k, l, m, n = 0 or 1; One or more double or triple bonds may be present (in which case two or more of R1-R24 are absent).