发明名称 |
CLAUDINS AS MARKERS FOR EARLY DETECTION, DIAGNOSIS, PROGNOSIS AND AS TARGETS OF THERAPY FOR BREAST AND METASTATIC BRAIN OR BONE CANCER |
摘要 |
Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue or cell samples. Claudins 1 and 7 are underexpressed in the majority of breast cancers, and claudins 3 and 4 are overexpressed. The methods of treatment involve the use of Clostridium perfringens enterotoxin (or a variant thereof) to lyse metastatic cancer cells in the brain and bone that overexpress claudins 3 and 4. |
申请公布号 |
WO03069307(A2) |
申请公布日期 |
2003.08.21 |
申请号 |
WO2003US04371 |
申请日期 |
2003.02.14 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;SUKUMAR, SARASWATI, V.;KOMINSKY, SCOTT, L. |
发明人 |
SUKUMAR, SARASWATI, V.;KOMINSKY, SCOTT, L. |
分类号 |
A61K38/16;A61K38/48;G01N33/574 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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