发明名称 |
Methods for detecting nucleic acid sequence variation |
摘要 |
Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.
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申请公布号 |
US2003157507(A1) |
申请公布日期 |
2003.08.21 |
申请号 |
US20020206561 |
申请日期 |
2002.07.25 |
申请人 |
THE GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES |
发明人 |
LIPSKY ROBERT H.;MAZZANTI CHIARA M.;GOLDMAN DAVID |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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