| 摘要 |
A two-step process for the preparation of fluoroolefin compounds of formula (I) wherein R is hydrogen or alkyl, and R<1> is alkyl or cyclopropyl, or R and R<1> are taken together with the carbon atom to which they are attached to form a cyclopropyl group; Ar is phenyl or naphthyl both of which are optionally substituted; Ar<1> is phenoxyphenyl, biphenyl, phenyl, benzylphenyl, or benzoylphenyl, all of which may be optionally substituted, comprising reacting fluorobromoolefin compounds of formula (II) with organozinc compounds of formula (III) (BrZnCH2Ar<1>) or (IV) (Zn(CH2Ar<1>)2) in the presence of a palladium catalyst and a solvent, which compounds of formula (II) are obtained by reacting aldehyde compounds of formula (V) with (a) fluorotribromomethane, (b) a tri(substituted)phosphine or a hexaalkylphosphoramide or a mixture thereof, and (c) zinc, in the presence of a solvent, compounds of formula (II). |
