Porcine complement regulator factor H and its use

摘要

Porcine complement regulator factor H (pFH) is capable of interacting with human molecules, e.g. human complement components and heparin, and showing enzymatic activity as a cofactor for human complement. In particular, but not exclusively, pFH exhibits regulatory functions for the complement system in different species. Accordingly, the invention relates to porcine complement regulator factor H (pFH) and to biologically and / or enzymatically active fragments, variants and mutants thereof, and to the use of such pFH as well as fragments, variants and mutants thereof to control complement activation. <IMAGE>