| 摘要 |
The invention provided for a method of directly transcriptionally modulating the expression of a gene encoding a gene product, the expression of which gene is associated with the production of the gene product. The invention further provides a method of directly transcriptionally modulating the expression of a gene encoding a protein of a virus, the expression of which is associated with a defined pathological effect caused by the virus within a multicellular organism. Screening methods, including methods of essentially simultaneously screening molecules to determine whether the molecules are capable of transcriptionally modulating one or more viral genes or other genes associated with the production of polypeptides or other desired products are also provided. Lastly, a method for directly transcriptionally modulating in a multicellular organism the expression of a gene encoding a viral gene, the expression of which is associated with a defined physiological or pathological effect caused by the virus, whose genome includes such a gene, in the organism, is provided. |
