NON-INVASIVE DIAGNOSTIC IMAGING TECHNOLOGY FOR MITOCHONDRIA DYSFUNCTION USING RADIOLABELED LIPOPHILIC SALTS

摘要

The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of .DELTA..PSI.m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging a nd detection of mitochondrial-related pathologies in patients using PET or SPEC T.