发明名称 |
Viral core protein-cationic lipid-nucleic acid-delivery complexes |
摘要 |
A nucleic acid delivery complex is provided which comprises a condensed polypeptide/nucleic acid complex and a cationic lipid wherein the complex comprises (a) a nucleic acide sequence of interest (NOI); and (b) one or more viral nucleic acid packaging polypeptides, or derivatives thereof, said polypeptides or derivatives thereof being (i) capable of binding to the NOI; and (ii) capable of condensing the NOI; and wherein the NOI is heterologous to the polypeptide. Also provided is a method of introducing an NOI into a cell using the delivery vector.
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申请公布号 |
US2003153081(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
US20030168909 |
申请日期 |
2003.01.13 |
申请人 |
TAGAWA TOSHIAKI;MILLER DAVID ANDREW;PEROUZEL ERIC;MURRAY KARL;MANVELL MICHELLE;ALTON ERIC;MATTHEWS DAVID;RUSSELL WILLIE |
发明人 |
TAGAWA TOSHIAKI;MILLER DAVID ANDREW;PEROUZEL ERIC;MURRAY KARL;MANVELL MICHELLE;ALTON ERIC;MATTHEWS DAVID;RUSSELL WILLIE |
分类号 |
C12N15/09;A61K9/127;A61K38/00;A61K47/48;A61K48/00;A61P25/00;A61P25/28;A61P35/00;A61P35/02;A61P43/00;C07K14/075;C12N7/04;C12N15/34;C12N15/88;(IPC1-7):C12N15/85;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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