发明名称 |
Responsive microgel and methods related thereto |
摘要 |
A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of "dangling chains' and wherein the "dangling chains' of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.
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申请公布号 |
US2003152623(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
US20020298808 |
申请日期 |
2002.11.18 |
申请人 |
BROMBERG LEV E.;TEMCHENKO MARINA |
发明人 |
BROMBERG LEV E.;TEMCHENKO MARINA |
分类号 |
A61K47/32;A61K8/02;A61K8/90;A61K9/00;A61K9/16;A61K9/22;A61K47/34;A61Q19/00;(IPC1-7):A61K9/22;A61K9/14 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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