Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to demonstrate their ability to serve as potent anti-HIV therapeutic molecules and thus, as therapeutic molecules or drugs.
申请公布号
WO0224735(A3)
申请公布日期
2003.08.14
申请号
WO2001US29637
申请日期
2001.09.21
申请人
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH;ECKERT, DEBRA, M.;SUNTOKE, TARA, R.;KIM, PETER, S.
发明人
ECKERT, DEBRA, M.;SUNTOKE, TARA, R.;KIM, PETER, S.