ANTICANCER AGENT COMPRISING NITROIMIDAZOLE AND TOPOISOMERASE INHIBITOR AS ACTIVE INGREDIENTS

摘要

The present invention relates to an anticancer agent comprising active ingredients of a nitroimidazole compound such as pimonidazole, misonidazole, etanidazole or ornidazole and a topoisomerase inhibitor such as doxorubicin, mitomycin C, camptothecin, novobiocin, epirubicin, dactinomycin or etoposide, and their pharmaceutically acceptable carrier. The anticancer agent induces apoptosis by the activity of topoisomerase inhibitor under the state of normoxia as well as by the activity of nitroimidazole compound under the state of hypoxia. Accordingly, the anticancer agent can be practically applied for the treatment of almost all kind of cancer, inter alia, solid cancer promoting the hypoxic condition regardless of the presence of oxygen.