PEROXIREDOXIN II-DEFICIENT MICE AND PRODUCTION METHOD THEREOF

摘要

PURPOSE: Provided are a peroxiredoxin II-deficient mice and a production method thereof which are useful for the study of oxidation or anti-oxidation mechanism in a blood cell and the development of a therapeutic agent for anemia. CONSTITUTION: A production method of a peroxiredoxin II-deficient mice is characterized by introducing a vector prxII-K.O which is deleted from peroxiredoxin II gene into a stem cell to give peroxiredoxin II deficient stem cell; micro-injecting the obtained peroxiredoxin II deficient stem cell into blastocoel to give a chimeric animal; and back crossing the chimeric animal.