| 摘要 |
<p>The present invention describes aliphatic polyoxaesters and blends thereof with other polymers that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I: ÄO-C(O)-C(R1)(R2)-O-(R3)-O-C(R1)(R2)-C(O)-Ü+ and two second repeating units of the formulas: Ä-O-R5-C(O)-ÜB , and (Ä-O-R13-C(O)ÜP-O-)LG wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: -Ä(CH2)C-O-ÜD-(CH2)E- wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of -C(R6)(R7)-, -(CH2)3-O-, -CH2-CH2-O-CH2-, -CR8H-CH2-, -(CH2)4-, -(CH2)F-O-C(O)- and -(CH2)K-C(O)-CH2-; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.</p> |
