| 发明名称 |
PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS |
| 摘要 |
A method for preparing an alkali metal salt comprising: (a) condensing a disilyloxydiene with an aldehyde in the presence of a titanium (IV) catalyst in an inert solvent to form a 5(S)~hydroxy-3-ketoester; (b) reducing the 5(S)- hydroxy-3-ketoester to a 3(R),5(S)-dihydroxyester in the presence of a di(lower alkyl)methoxyborane; and (c) hydrolyzing the 3(R),5(S)~dihydroxyester in the presence of an aqueous base to form an alkali metal salt.
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| 申请公布号 |
CA2472340(A1) |
申请公布日期 |
2003.08.07 |
| 申请号 |
CA20032472340 |
申请日期 |
2003.01.27 |
| 申请人 |
NOVARTIS AG |
发明人 |
LOESER, ERIC M.;KAPA, PRASAD KOTESWARA;CHEN, GUANG-PEI;GIRGIS, MICHAEL J.;ZAUGG, WERNER;BEUTLER, ULRICH |
| 分类号 |
C07B53/00;C07B61/00;C07D;C07D215/14;C07D405/06;(IPC1-7):C07D215/14;C07D239/42;C07D213/55 |
主分类号 |
C07B53/00 |
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