| 发明名称 |
Hybrid oligonucleotide phosphorothioates |
| 摘要 |
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
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| 申请公布号 |
US2003148980(A1) |
申请公布日期 |
2003.08.07 |
| 申请号 |
US20020265645 |
申请日期 |
2002.10.08 |
| 申请人 |
WORCESTER FOUNDATION FOR EXPERIMENTAL BIOLOGY |
发明人 |
METELEV VALERI;AGRAWAL SUDHIR |
| 分类号 |
C07H21/00;C07H21/04;C12N15/113;F15B13/00;F15B13/08;(IPC1-7):A61K48/00;C07H21/02 |
主分类号 |
C07H21/00 |
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