METHODS

摘要

A method for assessing a patient’s risk of development or progression of liver cirrhosis, comprising the step of determining the patient’s genotype or phenotype for a coagulation factor. If the patient's genotype is a genotype associated with a procoagulant tendency or the patient’s phenotype is a procoagulant tendency or indicative of a procoagulant tendency, then the patient is considered to be at a higher risk of developing liver cirrhosis or fibrosis and/or of rapid progression of liver cirrhosis or fibrosis. The coagulation factor may be Factor V. Patients with Factor V Leiden may be at a higher risk of developing liver cirrhosis or fibrosis and/or of rapid progression of liver cirrhosis or fibrosis.