METHOD OF LINE RETRO-POSITION

摘要

It is intended to provide a method of LINE retro−position. Namely, a method which comprises transferring an RNA containing a 3’ URT fragment of a LINE in cells and then trans−positioning the ORF protein of the LINE to thereby retro−transposition the RNA. A method of modifying a retro−transposition target site of a LINE by substituting the endonuclease domain of the LINE by the endonuclease domain of another LINE. This LINE retro−transposition method is useful in transferring a novel gene.