| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for manufacturing a 2-fluoro-2-methylpropionic acid in a high yield in a mild condition, wherein a fluorinating agent and a F source as a catalyst can be recovered and reused. SOLUTION: This method for manufacturing the 2-fluoro-2-methylpropionic acid is characterized by reacting a compound shown in formula (1) with HF (wherein, a substituent R is hydrogen atom, an alkyl group or an aryl group which may have a substituent, X is methylsulfonyl group, trifluoromethylsulfonyl group or trifluoroacetyl group). COPYRIGHT: (C)2003,JPO
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