| 摘要 |
The present invention relates to compounds of the general formulawhereinR<1 >is C6-10-cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl;R<2 >is hydrogen; lower alkyl; =O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy;is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy;X is -CH(OH)-; -C(O)-; -CHR<3>-; -CR<3>=; -O-; -S-; -CH(COOR<4>)- or C(COOR<4>)=;Y is -CH2-; -CH=; -CH(COOR<4>)-, -C(COOR<4>)=; or -C(CN)-;R<3 >is hydrogen or lower alkoxy;R<4 >is lower alkyl, cycloalkyl, phenyl, or benzyl andeither a or b is optionally an additional bond,and to pharmaceutically acceptable acid addition salts thereof.The compounds are agonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
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