发明名称 |
Process for producing optically active carboxylic acid subtituted in 2-position |
摘要 |
A nitrous acid salt is added at a temperature of 10 to 80 C. to an aqueous solution which contains an optically active 2-aminocarboxylic acid (4) and a protonic acid, the amount of the latter acid being 1 to 3 equivalents to the former, and which has a proton concentration of 0.5 to 2 mol/kg to conduct a reaction to thereby produce an optically active 2-hydroxycarboxylic acid (1). Thionyl chloride and a basic compound are caused to act on the compound (1) to chlorinate it and simultaneously invert the configuration in the 2-position. Thus, an optically active 2-chlorocarboxylic acid chloride (5) is induced. The compound (5) is hydrolyzed to induce an optically active 2-chlorocarboxylic acid (2). The compound (2) is reacted with a thioacetic acid salt to incorporate an acetylthio group thereinto and simultaneously invert the configuration in the 2-position to thereby produce an optically active 2-acetylthiocarboxylic acid (3)
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申请公布号 |
US2003144546(A1) |
申请公布日期 |
2003.07.31 |
申请号 |
US20020182260 |
申请日期 |
2002.09.25 |
申请人 |
AMANO SUSUMU;MITSUDA MASARU;INOUE KENJI;KINOSHITA KOICHI;YAMASHITA KOKI;UEDA YASUYOSHI |
发明人 |
AMANO SUSUMU;MITSUDA MASARU;INOUE KENJI;KINOSHITA KOICHI;YAMASHITA KOKI;UEDA YASUYOSHI |
分类号 |
C07C51/04;C07C51/367;C07C51/60;C07C59/48;C07C327/32;(IPC1-7):C07C323/22;C07C57/72;C07C57/64;C07C59/01;C07C59/11 |
主分类号 |
C07C51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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