FUSED POLYPEPTIDE OR ITS SALT, EXPRESSING VECTOR AND PHARMACEUTICAL COMPOSITION DESIGNATED FOR TREATMENT OF IGE-MEDIATED DISEASES

摘要

FIELD: genetic engineering, medicine, pharmacy. SUBSTANCE: invention relates to the fused polypeptide or its salt that comprises at least one IgE-binding domain with at least one component of human serum albumin (HAS). IgE-Binding domain is IgER or pre-IgER. Amino acid sequence is given in the description. Expressing vector comprises nucleotide sequence encoding the fused polypeptide. Pharmaceutical composition comprises the fused polypeptide or its salt taken in the effective dose and pharmaceutically acceptable carriers or excipients. Invention provides preparing pharmaceutical composition used for treatment of patients with IgE-mediated allergic diseases and associated disturbances, such as atopic dermatitis, atopic asthma and chronic nettle rash. EFFECT: valuable medicinal properties of polypeptide or its salts. 6 cl, 18 dwg, 8 ex