Compounds and methods for treatment of asthma, allergy and inflammatory disorders

摘要

A compound of formula (I), wherein: X and X' are independently hydrogen, halo, alkyl, alkenyl, alkynyl, alkoxy, trifluoromethyl or -(Y')m'-W', G and G' together form >HC-N<, D is -CH= or =N-, R1 and R2 independently are hydrogen or together are -(CH2)n- in which n is equal to 0, 1, 2, or 3, m and m' are independently 0 or 1, Y and Y' are -L1- or -L2-V(Z)t-L3- in which t is 0 or 1, Q, Q', and Q'' independently are hydrogen, -AC(O)OR6, or -AC(O)NR6R7, W and W' independently are -N(OM)C(O)N(R8)R9, -N(R8)C(O)N(OM)R9, -N(OM)C(O)R8, -C(O)NR8R9, or -C(O)OR8, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are independently hydrogen, alkly, alkenyl, alkynyl, aryl, arylalkyl, alkylaryl, alkylarylalkyl, or one of the foregoing in which one or more methylenes are replaced by -O-, -NH-, -S-, -S(O)-, or -S(O)2- and one or more methylidenes are replaced by =N-. Also disclosed is the use of the compounds of formula (I) in the manufacture of a medicament for simultaneously inhibiting both leukotriene- and histamine- mediated biological processes.