发明名称 |
HIV-1 VIRUS TAT-PROTEIN MUTANTS |
摘要 |
<p>The invention relates to the use of a protein mutation method for preparing detoxified and immunogenic mutants of the wild-type HIV-1 virus Tat-protein. The invention also relates to a method for preparing detoxified and immunogenic mutants of the wild-type HIV-1 virus Tat-protein, comprising a first step in which wild-type Tat-protein mutants are prepared, a second step in which detoxified mutants having no transcellular activity but an altered nuclear localization are screened, and a third step in which immunogenic mutants capable of inducing antibodies directed against both mutants and the wild Tat protein are screened. Steps two and three are reversible.</p> |
申请公布号 |
AU2003214299(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
AU20030214299 |
申请日期 |
2003.01.09 |
申请人 |
BIOMERIEUX S.A. |
发明人 |
AURELIE CHEDAL-BORNU;BERNARD VERRIER;BERNARD MANDRAND;CHRISTOPHE GUILLON |
分类号 |
A61K39/21;A61P31/18;C07K14/16;C12N15/48;C12N15/49;(IPC1-7):C12N15/49;C12N5/10;C07K16/10;G01N33/53;G01N33/566 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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