| 发明名称 |
PROTEASES PRODUCING AN ALTERED IMMUNOLOGICAL RESPONSE AND METHODS OF MAKING AND USING THE SAME |
| 摘要 |
<p>The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.</p> |
| 申请公布号 |
AU2002353178(A1) |
申请公布日期 |
2003.07.24 |
| 申请号 |
AU20020353178 |
申请日期 |
2002.12.20 |
| 申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
DAVID, A. ESTELL;FIONA, A HARDING |
| 分类号 |
C12N15/09;A61K8/00;A61K8/02;A61K8/06;A61K8/30;A61K8/33;A61K8/34;A61K8/36;A61K8/365;A61K8/55;A61K8/58;A61K8/64;A61K8/66;A61K8/67;A61K8/72;A61K8/86;A61K38/46;A61P17/16;A61Q19/00;A61Q19/10;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/54;C12N9/56;C12R1/07;(IPC1-7):A61K38/43;C12N15/52;C07K14/32;A61K39/07;C12N15/63 |
主分类号 |
C12N15/09 |
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