Methods and compositions are provided for the controlled release of an active agent. The composition includes an oligonucleotide scaffold and a substantially complementary oligonucleotide factor. An active agent is attached to the oligonucleotide factor. The two oligonucleotides are differentially degradable, so that degradation of the scaffold occurs a faster rate than the degradation of the factor. As the scaffold degrades, the factor is released. The active agent can be a therapeutic agent, or a diagnostic agent.
申请公布号
WO03060142(A2)
申请公布日期
2003.07.24
申请号
WO2002US33558
申请日期
2002.10.17
申请人
ESSENTIA BIOSYSTEMS, INC.;WONG, ARTHUR, H.;WAUGH, JACOB, M.;DAKE, MICHAEL, D.
发明人
WONG, ARTHUR, H.;WAUGH, JACOB, M.;DAKE, MICHAEL, D.