发明名称 |
Vaccination method |
摘要 |
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. There is also provided a method of inducing a CD4+ T-cell response against a target antigen, by administering a composition comprising a source of one or more CD4+ T cell epitopes of the target antigen wherein the source of CD4+ epitopes is a non-replicating or replication impaired recombinant poxvirus vector. A method of inducing a combined CD4+ and CD8+ T cell response against a target antigen is also described herein.
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申请公布号 |
US2003138454(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
US20020079167 |
申请日期 |
2002.02.19 |
申请人 |
OXXON PHARMACCINES, LTD. |
发明人 |
HILL ADRIAN V. S.;MCSHANE HELEN;GILBERT SARAH C.;REECE WILLIAM;SCHNEIDER JOERG |
分类号 |
A61K39/00;A61K39/015;A61K39/04;A61K39/145;A61K39/21;A61K39/39;C07K14/16;C07K14/445;C12N15/86;(IPC1-7):G01N33/53;C12N15/00;C07K5/00;A61K38/00;G01N33/537;A61K39/38;C12N15/09;C07K7/00;A61K38/04;G01N33/543;A61K39/285;C12N15/70;C07K17/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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