METHODS FOR CONSTRUCTION AND SCREENING OF LIBRARIES OF CHEMOKINE VARIANTS
摘要
The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
申请公布号
WO03022884(A3)
申请公布日期
2003.07.24
申请号
WO2002EP11045
申请日期
2002.09.05
申请人
UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI);UNIVERSITE DE GENEVE;GOROCHOV, GUY;HARTLEY, OLIVER;DORGHAM, KARIM;DEBRE, PATRICE;OFFORD, ROBIN
发明人
GOROCHOV, GUY;HARTLEY, OLIVER;DORGHAM, KARIM;DEBRE, PATRICE;OFFORD, ROBIN