发明名称 |
GENERATION OF RECOMBINANT ADENO-ASSOCIATED VIRAL VECTORS BY A COMPLETE ADENOVIRUS-MEDIATED APPROACH |
摘要 |
A complete virus-mediated system for recombinant AAV production including: (a) a first recombinant adenovirus encoding one or more AAV REP78/68 polypeptides and one or more viral capsid polypeptides; (b) a second recombinant adenovirus encoding a gene of interest and including AAV inverted terminal repeats, wherein the AAV inverted terminal repeats flank the gene of interest; (c) viral helper functions; and (d) a host cell transduced with the first recombinant adenovirus, the second recombinant adenovirus, and the viral helper functions.
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申请公布号 |
CA2369985(A1) |
申请公布日期 |
2003.07.18 |
申请号 |
CA20022369985 |
申请日期 |
2002.02.11 |
申请人 |
DUKE UNIVERSITY |
发明人 |
ZHANG, XIUWU;LI, CHUAN-YUAN |
分类号 |
A61K48/00;C12N5/08;C12N7/00;C12N15/35;C12N15/861;C12N15/864;(IPC1-7):C12N15/35;C07K14/015;C12N5/10;A61K39/235;C12Q1/70 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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