发明名称 |
RECOMBINANT TUMOR SPECIFIC ANTIBODY AND USE THEREOF |
摘要 |
The invention provides a family of antibodies that specifically bind the human epithelial cell adhesion molecule. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies, when coupled to the appropriate moiety, may be used in the diagnosis, prognosis and treatment of cancer. |
申请公布号 |
WO02090566(A3) |
申请公布日期 |
2003.07.17 |
申请号 |
WO2002US13844 |
申请日期 |
2002.05.03 |
申请人 |
LEXIGEN PHARMACEUTICALS CORP. |
发明人 |
GILLIES, STEPHEN, D.;LO, KIN-MING;QIAN, XIUQI |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P35/00;A61P37/02;A61P43/00;C07K16/18;C07K16/30;C07K16/46;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|