ANTIBODY AGAINST FIBROBLAST GROWTH FACTOR-23

摘要

It is intended to provide antibodies against fibroblast growth factor 23. Namely, antibodies having an activity of controlling phosphate metabolism or vitamin D metabolism and corresponding to the following (a), (b) or (c), which are obtained by immunizing an animal with a polypeptide comprising the amino acid sequence represented by SEQ ID NO:1 or a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion, substitution or addition of one to several amino acids and having a fibroblast growth factor 23 activity. (a) An antibody recognizing an amino acid sequence of the 180- to 194 positions or the 237- to 251-positions in the amino acid sequence represented by SEQ ID NO:1. (b) An antibody produced by a hybridoma represented by the accession number FERM BP-7838, FERM BP-7839, FERM BP-7840 or FERM BP-8268. (c) An antibody competing with an antibody produced by a hybridoma represented by the accession number FERM BP-7838, FERM BP-7839, FERM BP-7840 or FERM BP-8268.