1,2,3,4-Tetrahydro-2-naphthalenamine derivative, process of its preparation, the derivative intended for use as a medicament and pharmaceutical preparation in which the derivative is comprised

摘要

1,2,3,4-Tetrahydro-2-naftalenaminov² deriv t obecn ho vzorce I, ve kter m R.sub.1.n. a R.sub.2.n. nez visle na sob znamenaj H, (C.sub.1-4.n.)alkyl, (C.sub.1-4.n.)alkoxy, (C.sub.1-4.n.)alkylthio, halogen, trifluormethyl, trifluormethoxy, kyano, (C.sub.2-5.n.)alkanoyl, (C.sub.1-4.n.)alkylsulfonyl nebo sulfamoyl, R.sub.3.n. znamen H, (C.sub.1-4.n.)alkyl, (C.sub.1-4.n.)alkoxy, halogen, kyano, (C.sub.2-5.n.)alkanoyl, karbamoyl, (C.sub.1-4.n.)alkylsulfonyloxy nebo trifluormethylsulfonyloxy a R.sub.4.n. a R.sub.5.n. nez visle na sob znamenaj H, (C.sub.1-4.n.)alkyl, hydroxy(C.sub.1-4.n.)alkyl nebo fenyl(C.sub.1-4.n.)alkyl, nebo R.sub.4.n. a R.sub.5.n. spole n s atomem dus ku, ke kter mu jsou v z ny, tvo° pyrrolidinyl, piperidinyl nebo piperazinyl, ve form voln b ze nebo ve form adi n soli s kyselinou. Vyn lez se d le t²k zp sobu p° pravy uveden ho deriv tu reakc slou eniny obecn ho vzorce II se slou eninou obecn ho vzorce III. Uveden² deriv t je pou iteln² jako l ivo, zejm na ur en pro l en epilepsie, mrtvice a poran n mozku nebo m chy. D le je pops n zp sob jeho p° pravy, farmaceutick² p° pravek obsahuj c uveden² deriv t jako · innou l tku a pou it tohoto deriv tu pro p° pravu uveden ho l iva./