发明名称 |
QUINOLONE CARBOXYLIC ACID DERIVATIVES IN CRYSTALLINE HYDRATE FORM |
摘要 |
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3- methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid dihydrate having the following formula: (see formula I) The crystal of this dihydrate exhibits excellent stability over the other crystal forms under various pharmaceutical formulation conditions such as moisture absorption and blending in solvents and, hence, it is a most advantageous crystal form in the manufacture of pharmaceuticals.
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申请公布号 |
CA2128601(C) |
申请公布日期 |
2003.07.15 |
申请号 |
CA19932128601 |
申请日期 |
1993.01.29 |
申请人 |
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发明人 |
NAGANO, HIROYUKI;SUZUKI, NOBUYUKI |
分类号 |
C07D401/04;(IPC1-7):C07D401/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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