发明名称 |
Inhibitors of farnesyl protein transferase. |
摘要 |
This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation. |
申请公布号 |
ZA200202907(B) |
申请公布日期 |
2003.07.14 |
申请号 |
ZA20020002907 |
申请日期 |
2002.04.12 |
申请人 |
ASTRAZENECA AB. |
发明人 |
FRANCIS THOMAS BOYLE;ZBIGNIEW MATUSIAK;JAMES MICHAEL WARDLEWORTH |
分类号 |
A61K31/40;A61K31/454;A61K31/4545;A61P35/00;A61P35/02;A61P43/00;C07D207/12;C07D401/12;C07D401/14 |
主分类号 |
A61K31/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|