摘要 |
<p>Ligands of nuclear receptors PPAR's (peroxisome proliferator-activated receptors) which are compounds selected from the group consisting of ascofuranone; and ascofuranone homologs and ascochlorin homologs having at least an orcyl aldehyde moiety wherein the hydrogen atom(s) of the hydroxyl group(s) at the 2-position and/or the 4-position of the orcyl aldehyde moiety are substituted by C1-15alkyl, C1-15alkenyl, CH2COOH, CH2COO (C1-15alkyl), C(C=O)(C1-15 alkyl), C(=O)(CH2)1-15COOH, nicotinoyl, isonicotinoyl, etc. These ligands are usable in preventing and/or treating diabetes; hypertension or cerebrovascular disorders; arteriosclerosis; complications of diabetes; chronic inflammation; cachexia; digestive cancers, etc.</p> |