| 摘要 |
<p>The present invention relates to a modified enzyme and its modification process and in particular a method of modifying enzyme properties comprising the steps of: (i) activating a carboxyl group of a side chain of an amino acid residue or carboxy terminal amino acid of said enzyme; and (ii) incubating said activated enzyme with guanidine-, aromatic- or aminosugar-based nucleophile or combinations thereof for sufficient time to link an guanidine-, aromatic- or aminosugar group of said nucleophile to said enzyme.</p> |
