发明名称 |
Quinolinone derivative pharmaceutical compositon and production method therefor |
摘要 |
A quinolinone derivative pharmaceutical composition comprising a quinolinone derivative represented by the structural formula (I): wherein the quinolinone derivative is in the form of particles, which have an average particle diameter of 0.5 to 10 mum and such a particle size distribution that particles having a particle diameter of 15 mum or less account for 90% or more of the totality of the particles, and also have a fusion enthalpy of 30 J/g or more, and the surface of the particles are coated with a water-soluble composition containing a water-soluble polymer, can quickly dissolve an active ingredient in the digestive tract and is also superior in long-term storage stability.
|
申请公布号 |
US2003130310(A1) |
申请公布日期 |
2003.07.10 |
申请号 |
US20020171982 |
申请日期 |
2002.06.17 |
申请人 |
DAINIPPON INK AND CHEMICALS, INC. |
发明人 |
KUBOTA RYUJI;ARAYA HIROSHI;OBATA KOUKI;KIMURA NOBUYUKI;FUKUI HIROYUKI;TAKAGAKI HIDETSUGU |
分类号 |
A61K9/16;A61K9/20;A61K31/4704;(IPC1-7):A61K31/470;A61K9/14;A61K9/50 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|