发明名称 |
Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
摘要 |
Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.
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申请公布号 |
US6586413(B2) |
申请公布日期 |
2003.07.01 |
申请号 |
US20010800274 |
申请日期 |
2001.03.05 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
LIANG BRUCE T.;JACOBSON KENNETH A. |
分类号 |
A61K31/00;A61K45/06;(IPC1-7):A61K31/70 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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