| 摘要 |
1. A method for promoting smoking cessation or reduction or preventing relapse smoking, which method comprises administering an effective, non-toxic amount of paroxetine or a pharmaceutically acceptable salt or solvate there of, to human in need thereof. 2. A method according to claim 1, wherein paroxetine is administered in a controlled release or delayed release formulation. 3. Use according to claim 2 wherein the paroxetine is administered orally. 4. A method according to claim 3, wherein the paroxetine is administered in a controlled release or delayed release formulation comprising (a) a deposit-core comprising an effective amount of paroxetine and having defined geometric form, and (b) a support-platform applied to said deposit-core, wherein said deposit-core contains paroxetine, and at least one member selected from the group consisting of (1) a polymeric material which swells on contact with water or aqueous liquids and a gellable polymeric material wherein the ratio of the said swellable polymeric material to said gellable polymeric material is in the range 1:9 to 9:1, and (2) a single polymeric material having both swelling and gelling properties, and wherein the support-platform is an elastic support, applied to said deposit-core so that it partially covers the surface of the deposit-core and follows changes due to hydration of the deposit-core and is slowly soluble and/or slowly gellable in aqueous fluids. 5. A method according to any one of claims 2 to 4 wherein the paroxetine is co-administered with a nicotine-containing smoking cessation aid. 6. Use of paroxetine or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for use in promoting smoking cessation or reduction or preventing relapse smoking. 7. Use according to claim 6 wherein the paroxetine is in the form of the free base or a pharmaceutically acceptable salt thereof. 8. Use according to claim 7 wherein the pharmaceutically acceptable salt of paroxetine is a crystalline hydrochloride. 9. Use according to claim 8 wherein the hydrochloride is the hemihydrate.
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